We observed an association between the minor T allele and lower HDL cholesterol levels (CC vs. Genotype of ADIPOQ gene polymorphism (rs822393) was evaluated. Anthropometric parameters, blood pressure, fasting blood glucose, C-reactive protein (CRP), insulin concentration, insulin resistance (HOMA-IR), lipid profile, adipokines levels, ratio adiponectin/leptin ratio and prevalence of MS were recorded.
Patients and Methods: The study involved a population of 1004 Caucasian adult obese subjects. The aim of this study was to describe the association of rs822393 with adiponectin levels, cardiovascular risk factors, diabetes mellitus type 2 and metabolic syndrome. Objectives: Some studies in the literature indicate that ADIPOQ rs822393 polymorphism functionally regulates adiponectin levels.
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View / Download Pdf Share at Facebook Abstract Cardiology and Cardiovascular Medicine 5 (2021): 61-72. Single Nucleotide Polymorphism of ADIPOQ Gene (Rs822393) Is Associated with Lipid Profile, Adiponectin Levels and Ratio of Adiponectin/Leptin ratio in Adult Obese Subjects. Received: 26 December 2020 Accepted: 04 January 2020 Published: 11 January 2021Ĭitation: Daniel de Luis, Olatz Izaola, David Primo, Rocio Aller. School of Medicine, Valladolid University, C/Los perales 16 Simancas, 47130 Valladolid Spain *Corresponding Author: Daniel de Luis, Endocrinology and Nutrition Research Center. Single Nucleotide Polymorphism of ADIPOQ Gene (Rs822393) Is Associated with Lipid Profile, Adiponectin Levels and Ratio of Adiponectin/Leptin ratio in Adult Obese Subjects Article Informationĭaniel de Luis *, Olatz Izaola, David Primo, Rocio AllerĮndocrinology and Nutrition Research Center, School of Medicine, Department of Endocrinology and Nutrition, Hospital Clinico Universitario, University of Valladolid, Valladolid, Spain
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